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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: FIG4 All Species: 14.55
Human Site: T346 Identified Species: 29.09
UniProt: Q92562 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q92562 NP_055660.1 907 103635 T346 M M P K P P I T L D Q A D P F
Chimpanzee Pan troglodytes NP_001108096 994 112372 T433 M M P K P P I T L D Q A D P F
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_868449 724 82529 S187 Q M L Q R F G S P I I I L N L
Cat Felis silvestris
Mouse Mus musculus Q91WF7 907 103428 T346 M M P K P P I T L D Q A D P F
Rat Rattus norvegicus Q9ES21 587 67020 P50 A V K K D V P P S A V T R P I
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001108095 903 103212 T341 M M P K P P I T L D Q A D P F
Frog Xenopus laevis Q6GM29 586 66938 P49 S G K K D I P P S A I T R A I
Zebra Danio Brachydanio rerio A1L244 586 66913 P49 T V R K D V P P S A V T R P I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9W0I6 592 67749 L55 S G G L V A N L R P T R R I C
Honey Bee Apis mellifera XP_394455 868 100794 D331 V P G H W S Q D V S K M V P K
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_796508 601 68417 L64 T L P Q I K D L L Q T L R H G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P42837 879 101728 P342 A S N L T T K P P I R I N V V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 91 N.A. 78.2 N.A. 95.1 21.8 N.A. N.A. 87.9 23.5 22 N.A. 20.8 48.7 N.A. 40.6
Protein Similarity: 100 91 N.A. 79.1 N.A. 98 37.9 N.A. N.A. 93.3 39.6 39 N.A. 37.7 66.6 N.A. 51.6
P-Site Identity: 100 100 N.A. 6.6 N.A. 100 13.3 N.A. N.A. 100 6.6 13.3 N.A. 0 6.6 N.A. 13.3
P-Site Similarity: 100 100 N.A. 20 N.A. 100 20 N.A. N.A. 100 6.6 20 N.A. 0 26.6 N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 34.4 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 53.2 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 17 0 0 0 0 9 0 0 0 25 0 34 0 9 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 % C
% Asp: 0 0 0 0 25 0 9 9 0 34 0 0 34 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 9 0 0 0 0 0 0 0 0 34 % F
% Gly: 0 17 17 0 0 0 9 0 0 0 0 0 0 0 9 % G
% His: 0 0 0 9 0 0 0 0 0 0 0 0 0 9 0 % H
% Ile: 0 0 0 0 9 9 34 0 0 17 17 17 0 9 25 % I
% Lys: 0 0 17 59 0 9 9 0 0 0 9 0 0 0 9 % K
% Leu: 0 9 9 17 0 0 0 17 42 0 0 9 9 0 9 % L
% Met: 34 42 0 0 0 0 0 0 0 0 0 9 0 0 0 % M
% Asn: 0 0 9 0 0 0 9 0 0 0 0 0 9 9 0 % N
% Pro: 0 9 42 0 34 34 25 34 17 9 0 0 0 59 0 % P
% Gln: 9 0 0 17 0 0 9 0 0 9 34 0 0 0 0 % Q
% Arg: 0 0 9 0 9 0 0 0 9 0 9 9 42 0 0 % R
% Ser: 17 9 0 0 0 9 0 9 25 9 0 0 0 0 0 % S
% Thr: 17 0 0 0 9 9 0 34 0 0 17 25 0 0 0 % T
% Val: 9 17 0 0 9 17 0 0 9 0 17 0 9 9 9 % V
% Trp: 0 0 0 0 9 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _